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Article

6-Desfluoroquinolones as HIV-1 Tat-Mediated Transcription Inhibitors

1 Jul 2010

Abstract excerpt

The current anti-HIV treatments fail to completely eradicate the virus in HIV-infected individuals, mainly as a result of a small pool of latently infected cells. This issue, together with the emergence of multidrug-resistant viruses, clearly highlights the need to find additional strategies. An overview of the Tat-mediated transcription inhibitors 6-desfluoroquinolones (6-DFQs), identified by our group, is given...

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PMID: 21426162
DOI: 10.4155/fmc.10.208

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