Article
2,4,5-Trisubstituted thiazole derivatives as HIV-1 NNRTIs effective on both wild-type and mutant HIV-1 reverse transcriptase: Optimization of the substitution of positions 4 and 5.
European journal of medicinal chemistry - 10 Nov 2016
Xu Zhongliang, Guo Jiamei, Yang Ying, Zhang Mengdi, Ba Mingyu, Li Zhenzhong, Cao Yingli, He Ricai, Yu Miao, Zhou Hua, Li Xiaoxi, Huang Xiaoshan, Guo Ying, Guo Changbin
Abstract excerpt
In our previous work, novel 2,4,5-trisubstituted thiazole derivatives (TSTs) were synthesized, and their activities were evaluated against HIV-1 reverse transcriptase. Some interesting results were obtained, which led us to a new discovery regarding these TSTs. In the present study, 21 new 2,4,5-trisubstituted thiazole derivatives were rationally designed and synthesized as HIV-1 non-nucleoside reverse...
Topics
Join the communities discussing this publication.