Article

Novel 1,3-Indanedione Analogues as Anti-Arthritic Agents Targeting Interleukin-6

2026-08-31

Abstract excerpt

<title>Abstract</title> <p> The interleukin-6(IL-6) signaling pathway plays a critical role in mediating inflammatory responses implicated in various diseases, including rheumatoid arthritis. The synthesis of new class of 1,3-indanedione AKS1-AKS12 was guided by their favorable binding affinities to the IL-6 receptor identified through in-silico approaches in wild and mutated-proteins. Characterization of synthe...

Identifiers and source

Literature Corpus work: 56c0680d-88fc-583a-9061-c459b6fc945b
DOI: 10.21203/rs.3.rs-10712619/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Novel 1,3-Indanedione Analogues as Anti-Arthritic Agents Targeting Interleukin-6DOI 10.21203/rs.3.rs-10712619/v1Read

Pinoresinol targets NF-κB alongside STAT3 pathway to attenuate IL-6-induced inflammationSemantic proximity Read

Dual targeting of NF-κB and JAK-STAT pathways by pinoresinol attenuates IL-6-mediated inflammation in differentiated THP-1 cellsSemantic proximity Read

New coumarin-piperazine derivatives alleviate inflammatory bowel diseases as IL-6 inhibitors by targeting NF-κB pathwaySemantic proximity Read

Pinoresinol targets NF-kB alongside STAT3 pathway to attenuate IL-6-induced inflammationSemantic proximity Read

A Dual Target-Directed Single Domain-Based Fusion Protein Against Interleukin-6 Receptor Decelerate Experimental Arthritis Progression Via Modulating JNK ExpressionSemantic proximity Read

Unveiling novel insights into human IL-6 - IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis.Semantic proximity Read

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of goutSemantic proximity Read

Immunomodulatory properties of HDAC6 inhibitors in cancer diseases: New chances for sophisticated drug design and treatment optimizationSemantic proximity Read

STAT3 Inhibitory Activities of Lignans Isolated from the Stems of <em>Lindera obtusiloba </em>BlumeSemantic proximity Read

Exploring the landscape of synthetic IL ‐6‐type cytokinesSemantic proximity Read

Anthraquinone derivatives as an immune booster and their therapeutic option against COVID-19Semantic proximity Read

Nifuroxazide Ameliorates Pulmonary Fibrosis By Blocking Myofibroblast Genesis And Stat3 Activation: A Drug Repurposing StudySemantic proximity Read