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Anthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma

12 Oct 2004

Abstract excerpt

BACKGROUND: Sputum cytology for the mass screening of lung carcinoma is a noninvasive, repeatable, and useful examination, but the detection rate is usually < 0.05% and the reliability is not high. METHODS: The anthracotic index (AI) and methylation status of the promoter regions of the p16, adenomatous polyposis coli (APC), and retinoic acid receptor-beta (RARbeta) genes were examined in 356 sputum specimens...

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PMID: 15481085
DOI: 10.1002/cncr.20643

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