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Methylation profile in tumor and sputum samples of lung cancer patients detected by spiral computed tomography: A nested case–control study

8 Sept 2005

Abstract excerpt

We evaluated the aberrant promoter methylation profile of a panel of 3 genes in DNA from tumor and sputum samples, in view of a complementary approach to spiral computed tomography (CT) for early diagnosis of lung cancer. The aberrant promoter methylation of RARbeta2, p16(INK4A) and RASSF1A genes was evaluated by methylation-specific PCR in tumor samples of 29 CT-detected lung cancer patients, of which 18 had...

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PMID: 16152615
DOI: 10.1002/ijc.21473

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