Article
Quantitative assessment of lung cancer associated with genes methylation in the peripheral blood.
Experimental lung research - 1 Jan 2000
Tan Shanjuan, Sun Changqing, Wei Xiaoling, Li Yanqiang, Wu Yongjun, Yan Zhen, Feng Feifei, Wang Jing, Wu Yiming
Abstract excerpt
BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide due mainly to late diagnosis and poor prognosis. Aberrant promoter methylation is an important mechanism for silencing of tumor suppressor genes during carcinogenesis and a promising tool for the development of molecular biomarkers. METHODS: We evaluated the p16, RASSF1A, and FHIT genes promoter methylation status in peripheral blood...
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