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Article

Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2006

Walker Nancy M, Simpson Janet E, Levitt Roy C, Boyle Kathryn T, Clarke Lane L

Abstract excerpt

Intestinal disease in cystic fibrosis (CF) mice closely mirrors aspects of obstructive syndromes in CF patients. The pathogenesis involves accumulation of mucoid debris in the crypts that fuse with intestinal content to form obstructing mucofeculant impactions. Treatment involves modalities that increase the fluidity of the luminal content, such as osmotic laxatives and liquid diets. We investigated the effects...

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Source

Identifiers

PMID: 16354791
DOI: 10.1124/jpet.105.094847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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