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Article

Polymorphisms in the osteopontin promoter affect its transcriptional activity.

Physiological genomics - 15 Dec 2004

Giacopelli Francesca, Marciano Renato, Pistorio Angela, Catarsi Paolo, Canini Silvana, Karsenty Gerard, Ravazzolo Roberto

Abstract excerpt

Understanding the molecular mechanisms that underlie regulation of transcription of the human osteopontin encoding gene (OPN) may help to clarify several processes, such as fibrotic evolution of organ damage, tumorigenesis and metastasis, and immune response, in which OPN overexpression is observed. With the aim to evaluate variants with functional effect on transcription, we have analyzed the promoter region and...

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Identifiers

PMID: 15479859
DOI: 10.1152/physiolgenomics.00138.2004

Genes

RUNX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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