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Article

The potential of the human osteopontin promoter and single-nucleotide polymorphisms for targeted cancer gene therapy.

Current gene therapy - 1 Jan 2015

Chen X G, Godbey W T

Abstract excerpt

Regulatory elements of the osteopontin (opn) gene are attractive candidates for expressiontargeted gene therapy because numerous malignant cancers are marked by opn overexpression. The maximum opn promoter ((P)opn)-driven reporter intensity obtained for tested cancer cell lines was as strong (102.69%) as positive-control transfections. At the same time, (P)opn-driven reporter expression was reduced by ~90% in...

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Identifiers

PMID: 25429464
DOI: 10.2174/1566523214666141127094033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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