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Article

In vitro functional assay of alleles and haplotypes of two COL1A1-promoter SNPs.

Bone - 1 May 2005

García-Giralt Natàlia, Enjuanes Anna, Bustamante Mariona, Mellibovsky Leonardo, Nogués Xavier, Carreras Ramón, Díez-Pérez Adolfo, Grinberg Daniel, Balcells Susana

Abstract excerpt

Osteoporosis is a common disease with a strong genetic component. We previously described two polymorphic sites in the COL1A1 gene promoter, -1997 G/T and -1663indelT, which have been associated with bone mineral density (BMD), a surrogate trait for osteoporosis. Here, we explore the molecular mechanisms underlying this association by performing transient transfections in MG-63 cells of constructs bearing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15814304
DOI: 10.1016/j.bone.2004.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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