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Article

The impact of osteopontin promoter polymorphisms on the risk of calcium urolithiasis.

Clinica chimica acta; international journal of clinical chemistry - 2 May 2010

Liu Chia-Chu, Huang Shu-Pin, Tsai Li-Yu, Wu Wen-Jeng, Juo Suh-Hang Hank, Chou Yii-Her, Huang Chun-Hsiung, Wu Ming-Tsang

Abstract excerpt

BACKGROUND: Osteopontin (OPN) is an important modulator of urolithiasis formation. Three functional polymorphisms (-66T/G, -156delG/G, and -443T/G) on the promoter region of the OPN gene have been found to affect the gene expression and transcriptional activity. This study investigated the association of those three functional polymorphisms with the risk of calcium urolithiasis. METHODS: A total of 249 cases...

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Identifiers

PMID: 20144595
DOI: 10.1016/j.cca.2010.02.007

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The impact of osteopontin promoter polymorphisms on the risk of calcium urolithiasis.PMID 20144595Read ↗

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