Article
Desmoglein 2 mutant mice develop cardiac fibrosis and dilation.
Basic research in cardiology - 1 Jun 2011
Krusche Claudia A, Holthöfer Bastian, Hofe Valérie, van de Sandt Annette M, Eshkind Leonid, Bockamp Ernesto, Merx Marc W, Kant Sebastian, Windoffer Reinhard, Leube Rudolf E
Abstract excerpt
Desmosomes are cell-cell adhesion sites and part of the intercalated discs, which couple adjacent cardiomyocytes. The connection is formed by the extracellular domains of desmosomal cadherins that are also linked to the cytoskeleton on the cytoplasmic side. To examine the contribution of the desmosomal cadherin desmoglein 2 to cardiomyocyte adhesion and cardiac function, mutant mice were prepared lacking a part...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.