Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3.

Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2004

Seabury Christopher M, Honeycutt Rodney L, Rooney Alejandro P, Halbert Natalie D, Derr James N

Abstract excerpt

Amino acid replacements encoded by the prion protein gene (PRNP) have been associated with transmissible and hereditary spongiform encephalopathies in mammalian species. However, an association between bovine spongiform encephalopathy (BSE) and bovine PRNP exon 3 has not been detected. Moreover, little is currently known regarding the mechanisms of evolution influencing the bovine PRNP gene. Therefore, in this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to Encephalopathy, Bovine Spongiform

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prions

Share to Repetitive Sequences, Amino Acid

Share to Ruminants

Share to Selection, Genetic

Share to Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 15477588
DOI: 10.1073/pnas.0406403101
PMCID: PMC524052

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3.PMID 15477588Read ↗

Sequence variation in the bovine and ovine PRNP genes.Semantic proximity Read ↗

Prion gene haplotypes of U.S. cattle.Semantic proximity Read ↗

Association of a bovine prion gene haplotype with atypical BSE.Semantic proximity Read ↗

Sequence variations of the bovine prion protein gene (PRNP) in native Korean Hanwoo cattle.Semantic proximity Read ↗

Effect of bovine PRNP gene polymorphisms on BSE susceptibility in cattle.Semantic proximity Read ↗

First Report of the Potential Bovine Spongiform Encephalopathy (BSE)-Related Somatic Mutation E211K of the Prion Protein Gene (PRNP) in Cattle.Semantic proximity Read ↗

Analysis of sequence variability of the bovine prion protein gene (PRNP) in German cattle breeds.Semantic proximity Read ↗

A 2cM genome-wide scan of European Holstein cattle affected by classical BSE.Semantic proximity Read ↗

Bovine spongiform encephalopathy (BSE)-associated polymorphisms of the prion protein (PRNP) gene in Korean native cattle.Semantic proximity Read ↗

A new allelic variant in the bovine prion protein gene (PRNP) coding region.Semantic proximity Read ↗

PRNP haplotype associated with classical BSE incidence in European Holstein cattle.Semantic proximity Read ↗

The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.