Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heritability of the aged glutathione phenotype is dependent on tissue of origin.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2018

Gould Rebecca L, Zhou Yang, Yakaitis Claire L, Love Kimberly, Reeves Jaxk, Kong Wenqian, Coe Erica, Xiao Yanfang, Pazdro Robert

Abstract excerpt

Glutathione is a ubiquitous antioxidant that protects cells against reactive oxygen species and other chemical stressors. Despite its functional importance, the impact of genetics on the glutathione system has yet to be fully appreciated. Here, we investigated the heritability of glutathione levels and redox status in a disease-relevant condition: advanced age. We assembled a panel of 18-21-month-old mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Myocardium
Share to Glutathione

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Mice, Inbred Strains

Share to Organ Specificity

Share to Pancreas

Share to Quantitative Trait, Heritable

Source

Identifiers

PMID: 30008145
DOI: 10.1007/s00335-018-9759-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heritability of the aged glutathione phenotype is dependent on tissue of origin.PMID 30008145Read ↗

Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse ModelSemantic proximity Read ↗

Redox theory of aging: implications for health and diseaseSemantic proximity Read ↗

Revisiting an age-old question regarding oxidative stress.Semantic proximity Read ↗

G6PD protects from oxidative damage and improves healthspan in miceSemantic proximity Read ↗

A high-fat diet differentially regulates glutathione phenotypes in the obesity-prone mouse strains DBA/2J, C57BL/6J, and AKR/J.Semantic proximity Read ↗

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.Semantic proximity Read ↗

Genetically altered mice to evaluate glutathione homeostasis in health and disease.Semantic proximity Read ↗

Reductive Stress Linked to Small HSPs, G6PD, and Nrf2 Pathways in Heart DiseaseSemantic proximity Read ↗

Mitochondrial‐targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy?Semantic proximity Read ↗

A mouse model to study glutathione limitation <i>in vivo</i>Semantic proximity Read ↗

Detoxification reactions: relevance to aging.Semantic proximity Read ↗

Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione poolsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.