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Article

Role of Dok1 in cell signaling mediated by RET tyrosine kinase.

The Journal of biological chemistry - 6 Sept 2002

Murakami Hideki, Yamamura Yumiko, Shimono Yohei, Kawai Kumi, Kurokawa Kei, Takahashi Masahide

Abstract excerpt

Using a yeast two-hybrid screen, we identified Dok1 as a docking protein for RET tyrosine kinase. Dok1 bound more strongly to RET with a multiple endocrine neoplasia (MEN) 2B mutation than RET with a MEN2A mutation and was highly phosphorylated in the cells expressing the former mutant protein. Analysis by site-directed mutagenesis revealed that tyrosine 361 in mouse Dok1 represents a binding site for the Nck...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12087092
DOI: 10.1074/jbc.M202336200

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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