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Article

Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2005

Boulay Iohann, Némorin Jean-Guy, Duplay Pascale

Abstract excerpt

To date, five members of the downstream of tyrosine kinase (Dok) family have been characterized. In T cells, two members, Dok-1 and Dok-2, are expressed. CD2 or CD28 stimulation, but not CD3/TCR stimulation, induces Dok phosphorylation. Recent evidence suggests that they act as negative regulators of the CD2 and CD28 signaling pathways. To identify the molecular mechanisms involved in Dok-mediated inhibition, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16177091
DOI: 10.4049/jimmunol.175.7.4483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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