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Article

Activation of calpain by Ca2+: roles of the large subunit N-terminal and domain III-IV linker peptides.

Journal of molecular biology - 29 Oct 2004

Hosfield Christopher M, Elce John S, Jia Zongchao

Abstract excerpt

The calpains are a family of cysteine proteases with closely related amino acid sequences, but a wide range of Ca(2+) requirements (K(d)). For m-calpain, K(d) is approximately 325microM, for mu-calpain it is approximately 50microM, and for calpain 3 it is not strictly known but may be approximately 0.1microM. On the basis of previous structure determination of m-calpain we postulated that two regions of the...

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Identifiers

PMID: 15476820
DOI: 10.1016/j.jmb.2004.08.073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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