Article
Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation.
FEBS letters - 8 May 2003
Smith Scott D, Jia Zongchao, Huynh Kassidy K, Wells Alan, Elce John S
Abstract excerpt
Regulation of calpain by phosphorylation has often been suggested, but has proved difficult to detect. Calpains extracted from mammalian tissue are reported to contain 2-4 mol phosphate/mol of enzyme distributed over multiple sites, but phosphate groups are not detectable in the X-ray structures...
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