Article
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
The Biochemical journal - 1 Oct 2002
Dutt Previn, Spriggs Cherie N, Davies Peter L, Jia Zongchao, Elce John S
Abstract excerpt
The mu- and m-calpains are closely related Ca(2+)-dependent cysteine proteases having different in vitro Ca(2+) requirements ( K (d)), of approx. 25 and 325 microM respectively. The two isoforms are heterodimers of slightly different large (80 kDa) subunits and an identical small (28 kDa) subunit, so that the difference in K (d) values must reside in the large subunits. As assayed here, these K (d) values relate...
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