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Article

Mechanism of μ-conotoxin PIIIA binding to the voltage-gated Na+ channel NaV1.4.

PloS one - 1 Jan 2014

Chen Rong, Robinson Anna, Chung Shin-Ho

Abstract excerpt

Several subtypes of voltage-gated Na+ (NaV) channels are important targets for pain management. μ-Conotoxins isolated from venoms of cone snails are potent and specific blockers of different NaV channel isoforms. The inhibitory effect of μ-conotoxins on NaV channels has been examined extensively, but the mechanism of toxin specificity has not been understood in detail. Here the known structure of μ-conotoxin...

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Identifiers

PMID: 24676211
DOI: 10.1371/journal.pone.0093267
PMCID: PMC3968119

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Source receipt: pubmed, retrieved 7 Sept 2026.

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