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Article

Modelling insecticide-binding sites in the voltage-gated sodium channel.

The Biochemical journal - 1 Jun 2006

O'Reilly Andrias O, Khambay Bhupinder P S, Williamson Martin S, Field Linda M, Wallace B A, Davies T G Emyr

Abstract excerpt

A homology model of the housefly voltage-gated sodium channel was developed to predict the location of binding sites for the insecticides fenvalerate, a synthetic pyrethroid, and DDT an early generation organochlorine. The model successfully addresses the state-dependent affinity of pyrethroid insecticides, their mechanism of action and the role of mutations in the channel that are known to confer insecticide...

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Source

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Identifiers

PMID: 16475981
DOI: 10.1042/BJ20051925
PMCID: PMC1462714

Genes

DDT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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