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[18F]Fluoro-2-deoxy-D-glucose positron emission tomography detects gastric carcinoma in an early stage in an asymptomatic E-cadherin mutation carrier.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2004

van Kouwen Mariette C A, Drenth Joost P H, Oyen Wim J G, de Bruin Joyce H F M, Ligtenberg Marjolijn J, Bonenkamp J J Han, van Krieken J Han J M, Nagengast Fokko M

Abstract excerpt

PURPOSE: Autosomal dominant hereditary diffuse gastric cancer (HDGC) is caused by germ-line E-cadherin (CDH1) gene mutations. Early detection of cancer in carriers is difficult because HDGC escapes endoscopic detection. We hypothesized that the glucose metabolism is enhanced in HDGC and that this...

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Identifiers

PMID: 15475432
DOI: 10.1158/1078-0432.CCR-04-0599

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15475432-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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