Article
Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction.
Vaccine - 22 Oct 2004
Behboudi Shahriar, Moore Anne, Gilbert Sarah C, Nicoll Claire L, Hill Adrian V S
Abstract excerpt
The administration of recombinant vaccinia virus Ankara (MVA) encoding a CTL epitope (pb9) from a malaria antigen induced activation and maturation of splenic dendritic cells (DCs) in vivo. In contrast, incubation of immature dendritic cells (iDCs) with the MVA, in vitro, resulted in down-regulation of MHC class I molecules and reduced their T-cell stimulatory ability. However, the ability of the infected DC to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.