Article
The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains.
Journal of virology - 1 Jul 2013
Lubaki Ndongala M, Ilinykh Philipp, Pietzsch Colette, Tigabu Bersabeh, Freiberg Alexander N, Koup Richard A, Bukreyev Alexander
Abstract excerpt
Ebola virus (EBOV) infections are characterized by deficient T lymphocyte responses, T lymphocyte apoptosis, and lymphopenia in the absence of direct infection of T lymphocytes. In contrast, dendritic cells (DC) are infected but fail to mature appropriately, thereby impairing the T cell response....
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