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Activation of human dendritic cells by recombinant modified vaccinia virus Ankara vectors encoding survivin and IL-2 genes in vitro.

Human gene therapy - 1 Jan 2010

Tao Ran, Li Lian, Huang Wenlin, Zheng Limin

Abstract excerpt

Modified vaccinia virus Ankara (MVA) has attracted significant attention as a safe, promising vector for immunotherapy. However, the precise effects of MVA infection on immune responses in humans remain largely unknown. We constructed recombinant MVA (rMVA) encoding both a human tumor-associated antigen (survivin) and the proinflammatory cytokine interleukin (IL)-2 and investigated their effects on human...

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PMID: 19715401
DOI: 10.1089/hum.2009.113

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