Article
N(2)-(1-Carboxyethyl)deoxyguanosine, a nonenzymatic glycation adduct of DNA, induces single-strand breaks and increases mutation frequencies.
Biochemical and biophysical research communications - 22 Oct 1999
Pischetsrieder M, Seidel W, Münch G, Schinzel R
Abstract excerpt
N(2)-(1-Carboxyethyl)deoxyguanosine (CEdG) is a major nonenzymatic glycation product of DNA. The effect of CEdG modification, which was specifically prepared by incubation with dihydroxyacetone, on plasmid DNA topology was evaluated by gel electrophoresis. A time-dependent decrease of supercoiled plasmid-DNA was observed in parallel to the increase of CEdG adducts; the half-life time of the supercoiled...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.