Article
A Pathogenic NRAS c.38G>A (p.G13D) Mutation in RARA Translocation-negative Acute Promyelocytic-like Leukemia with Concomitant Myelodysplastic Syndrome.
Internal medicine (Tokyo, Japan) - 1 May 2023
Goto Hideaki, Yakushijin Kimikazu, Adachi Yoko, Matsumoto Hisayuki, Yamamoto Katsuya, Matsumoto Sakuya, Yamashita Tomoe, Higashime Ako, Kawaguchi Koji, Kurata Keiji, Matsuoka Hiroshi, Minami Hironobu
Abstract excerpt
An acute promyelocytic leukemia (APL) patient not demonstrating the retinoic acid receptor α (RARA) translocation is rare. A 76-year-old man was diagnosed with myelodysplastic syndrome (MDS). After a year, abnormal promyelocytes were detected with pancytopenia and disseminated intravascular coagulopathy. Morphologically, the patient was diagnosed with APL; however, a genetic examination failed to detect RARA...
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