Article
Rare occurrence of DNMT3A mutations in myelodysplastic syndromes.
Haematologica - 1 Dec 2011
Thol Felicitas, Winschel Claudia, Lüdeking Andrea, Yun Haiyang, Friesen Inna, Damm Frederik, Wagner Katharina, Krauter Jürgen, Heuser Michael, Ganser Arnold
Abstract excerpt
Gene mutations and epigenetic changes have been shown to play significant roles in the pathogenesis of myelodysplastic syndromes. Recently, mutations in DNMT3A were identified in 22.1% of patients with acute myeloid leukemia. In this study, we analyzed the frequency and clinical impact of DNMT3A mutations in a cohort of 193 patients with myelodysplastic syndromes. Mutations in DNMT3A were found in 2.6% of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.