Article
Detection of mutations associated with isoniazid and rifampin resistance in Mycobacterium tuberculosis isolates from Samara Region, Russian Federation.
Journal of clinical microbiology - 1 Oct 2004
Nikolayevsky V, Brown T, Balabanova Y, Ruddy M, Fedorin I, Drobniewski F
Abstract excerpt
High incidence rates of isoniazid-, rifampin-, and multiple-drug-resistant tuberculosis have been reported in countries of the former Soviet Union (FSU). Genotypic (unlike phenotypic) drug resistance assays do not require viable cultures but require accurate knowledge of both the target gene and the mutations associated with resistance. For these assays to be clinically useful, they must be able to detect the...
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