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Article

Pyrosequencing for rapid detection of Mycobacterium tuberculosis resistance to rifampin, isoniazid, and fluoroquinolones.

Journal of clinical microbiology - 1 Dec 2009

Bravo Lulette Tricia C, Tuohy Marion J, Ang Concepcion, Destura Raul V, Mendoza Myrna, Procop Gary W, Gordon Steven M, Hall Geraldine S, Shrestha Nabin K

Abstract excerpt

After isoniazid and rifampin (rifampicin), the next pivotal drug class in Mycobacterium tuberculosis treatment is the fluoroquinolone class. Mutations in resistance-determining regions (RDR) of the rpoB, katG, and gyrA genes occur with frequencies of 97%, 50%, and 85% among M. tuberculosis isolates resistant to rifampin, isoniazid, and fluoroquinolones, respectively. Sequences are highly conserved, and certain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19846642
DOI: 10.1128/JCM.01229-09
PMCID: PMC2786679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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