Article
A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia.
Antimicrobial agents and chemotherapy - 1 Sept 1998
Marttila H J, Soini H, Eerola E, Vyshnevskaya E, Vyshnevskiy B I, Otten T F, Vasilyef A V, Viljanen M K
Abstract excerpt
Parts of katG and rpoB from 27 Russian Mycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutated katG, and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shift. An rpoB mutation was noted for each of the 21 RMP-resistant isolates, with Ser531Leu being the most prevalent...
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