The role of packing interactions in stabilizing folded proteins.

doi:10.1021/bi00125a028

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Article

The role of packing interactions in stabilizing folded proteins.

Biochemistry - 17 Mar 1992

Sneddon S F, Tobias D J

Abstract excerpt

In order to investigate the role of nonpolar side chains in determining protein stability, we have carried out a molecular dynamics simulation study of the thermodynamics of interconverting isoleucine and valine side chains in the core of ribonuclease T1. The free energy change in the unfolded st...

Topics

Isoleucine
Mutation
Protein Conformation
Ribonuclease T1
Thermodynamics
Valine

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