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Article

The role of packing interactions in stabilizing folded proteins.

Biochemistry - 17 Mar 1992

Sneddon S F, Tobias D J

Abstract excerpt

In order to investigate the role of nonpolar side chains in determining protein stability, we have carried out a molecular dynamics simulation study of the thermodynamics of interconverting isoleucine and valine side chains in the core of ribonuclease T1. The free energy change in the unfolded state, which we take to be fully solvated, was small and agrees qualitatively with experimental studies of alkane...

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PMID: 1547226
DOI: 10.1021/bi00125a028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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