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Article

Prediction of protein solubility from calculation of transfer free energy.

Biophysical journal - 15 Sept 2008

Tjong Harianto, Zhou Huan-Xiang

Abstract excerpt

Solubility plays a major role in protein purification, and has serious implications in many diseases. We studied the effects of pH and mutations on protein solubility by calculating the transfer free energy from the condensed phase to the solution phase. The condensed phase was modeled as an implicit solvent, with a dielectric constant lower than that of water. To account for the effects of pH, the protonation...

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Identifiers

PMID: 18515380
DOI: 10.1529/biophysj.107.127746
PMCID: PMC2527251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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