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Article

Unspecific hydrophobic stabilization of folding transition states.

Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002

Viguera Ana Rosa, Vega Cristina, Serrano Luis

Abstract excerpt

Here we present a method for determining the inference of non-native conformations in the folding of a small domain, alpha-spectrin Src homology 3 domain. This method relies on the preservation of all native interactions after Tyr/Phe exchanges in solvent-exposed, contact-free positions. Minor changes in solvent exposure and free energy of the denatured ensemble are in agreement with the reverse hydrophobic...

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Identifiers

PMID: 11959988
DOI: 10.1073/pnas.072387799
PMCID: PMC122772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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