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Article

The role of the unfolded state in hairpin stability.

Biophysical journal - 1 Dec 2003

Lei Hongxing, Smith Paul E

Abstract excerpt

The effects of a T3S mutation on the stability of a 3:5 beta-hairpin forming peptide (YITNSNGTWT) are investigated. Molecular dynamics simulations in explicit water indicate that the wild-type peptide forms a stable hairpin whereas the T3S mutant does not, in agreement with the experimental data. Thermodynamic integration calculations for the mutation of Thr to Ser suggest that the free-energy changes in the...

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Identifiers

PMID: 14645046
DOI: 10.1016/S0006-3495(03)74771-7
PMCID: PMC1303658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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