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Article

Native-state energetics of a thermostabilized variant of ribonuclease HI.

Journal of molecular biology - 7 Dec 2001

Goedken E R, Marqusee S

Abstract excerpt

Escherichia coli RNase HI is a well-characterized model system for protein folding and stability. Controlling protein stability is critical for both natural proteins and for the development of engineered proteins that function under extreme conditions. We have used native-state hydrogen exchange on a variant containing the stabilizing mutation Asp10 to alanine in order to determine its residue-specific...

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Identifiers

PMID: 11734003
DOI: 10.1006/jmbi.2001.5184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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