Article
Frequent c-Kit gene mutations not only in gastrointestinal stromal tumors but also in interstitial cells of Cajal in surrounding normal mucosa.
Cancer letters - 18 Dec 2005
Ogasawara Naotaka, Tsukamoto Tetsuya, Inada Kenichi, Mizoshita Tsutomu, Ban Naoko, Yamao Kenji, Joh Takashi, Itoh Makoto, Tatematsu Masae
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are thought to originate from mesenchymal stem cells that differentiate toward the interstitial cells of Cajal (ICCs). The frequent occurrence of activating mutations involving exon 11 of c-Kit gene in sporadic GISTs indicates an important role in genesis of this tumor type. In the present study we examined c-Kit gene mutations in a series of GISTs and also in ICCs of...
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