Article
Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae.
Molecular biology of the cell - 1 Nov 1997
Dolinski K, Scholz C, Muir R S, Rospert S, Schmid F X, Cardenas M E, Heitman J
Abstract excerpt
Cyclophilin and FK506 binding protein (FKBP) accelerate cis-trans peptidyl-prolyl isomerization and bind to and mediate the effects of the immunosuppressants cyclosporin A and FK506. The normal cellular functions of these proteins, however, are unknown. We altered the active sites of FKBP12 and m...
Topics
- Binding Sites
- Carrier Proteins
- DNA-Binding Proteins
- Heat-Shock Proteins
- Humans
- Mitochondria
- Mutation
- Peptidylprolyl Isomerase
- Protein Folding
- Recombinant Fusion Proteins
- Ribonuclease T1
- Saccharomyces cerevisiae
- Tacrolimus Binding Proteins
- Tetrahydrofolate Dehydrogenase