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Article

Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues.

Brain : a journal of neurology - 1 Nov 2004

Corti Stefania, Locatelli Federica, Donadoni Chiara, Guglieri Michela, Papadimitriou Dimitra, Strazzer Sandra, Del Bo Roberto, Comi Giacomo P

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease without any effective therapy. To evaluate the potential of wild-type bone marrow (BM)-derived stem cells to modify the ALS phenotype, we generated BM chimeric Cu/Zn superoxide dismutase (SOD1) mice by transplantation of BM cells derived from mice expressing green fluorescent protein (GFP) in all tissues and from Thy1-YFP mice...

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PMID: 15469951
DOI: 10.1093/brain/awh273

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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