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Stable fusion of bone marrow-derived cells with Purkinje neurons enables long-term nuclear integration and neuronal repair

2025-12-31

Abstract excerpt

Developing effective strategies to replace or restore injured neurons could significantly revolutionise the treatment of currently incurable neurodegenerative disorders. Studies have shown that bone marrow-derived cells (BMDCs) can migrate into the brain and fuse with damaged Purkinje neurons (PNs), restoring their structure and function. Yet, despite over two decades of research, the temporal dynamics and functio...

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Literature Corpus work
ec8f0c3e-940e-5772-946e-818281027ba3
DOI
10.64898/2025.12.31.694485
Open publication

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Stable fusion of bone marrow-derived cells with Purkinje neurons enables long-term nuclear integration and neuronal repairDOI 10.64898/2025.12.31.694485
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