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Article

Myelosuppressive conditioning using busulfan enables bone marrow cell accumulation in the spinal cord of a mouse model of amyotrophic lateral sclerosis.

PloS one - 1 Jan 2013

Lewis Coral-Ann B, Manning John, Barr Christine, Peake Kyle, Humphries R Keith, Rossi Fabio, Krieger Charles

Abstract excerpt

Myeloablative preconditioning using irradiation is the most commonly used technique to generate rodents having chimeric bone marrow, employed for the study of bone marrow-derived cell accumulation in the healthy and diseased central nervous system. However, irradiation has been shown to alter the blood-brain barrier, potentially creating confounding artefacts. To better study the potential of bone marrow-derived...

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Identifiers

PMID: 23593276
DOI: 10.1371/journal.pone.0060661
PMCID: PMC3620474

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