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Article

Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii.

The Journal of biological chemistry - 17 Dec 2004

Yarovinsky Felix, Andersen John F, King Lisa R, Caspar Patricia, Aliberti Julio, Golding Hana, Sher Alan

Abstract excerpt

The protozoan parasite Toxoplasma gondii possesses a protein, cyclophilin-18 (C-18), which binds to the chemokine receptor CCR5, induces interleukin-12 production from murine dendritic cells, and inhibits fusion and infectivity of human immunodeficiency virus 1 (HIV-1) R5 viruses by co-receptor antagonism. Site-directed mutagenesis was employed to identify the domains in C-18 responsible for its CCR5 binding and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15469936
DOI: 10.1074/jbc.M410550200

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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