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Article

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion.

PloS one - 1 Jan 2014

Leung Jacqueline M, Tran Fanny, Pathak Ravindra B, Poupart Séverine, Heaslip Aoife T, Ballif Bryan A, Westwood Nicholas J, Ward Gary E

Abstract excerpt

Motility of the protozoan parasite Toxoplasma gondii plays an important role in the parasite's life cycle and virulence within animal and human hosts. Motility is driven by a myosin motor complex that is highly conserved across the Phylum Apicomplexa. Two key components of this complex are the class XIV unconventional myosin, TgMyoA, and its associated light chain, TgMLC1. We previously showed that treatment of...

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PMID: 24892871
DOI: 10.1371/journal.pone.0098056
PMCID: PMC4043638

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Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion.PMID 24892871Read ↗

A Small-Molecule Inhibitor of T. gondii Motility Induces the Posttranslational Modification of Myosin Light Chain-1 and Inhibits Myosin Motor ActivitySemantic proximity Read ↗

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