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Article

Ras/Raf/ERK signalling and NF1: Implications for Neurofibroma Formation

12 Oct 2004

Abstract excerpt

Ras signalling is important in the development of Schwann-cell-derived tumors in Neurofibromatosis Type 1 (NF1) patients. Schwann cells are a regenerative cell type, with no known stem-cell population. To produce new cells in the adult, for example following nerve damage, myelinating Schwann cells de-differentiate, proliferate and then re-differentiate during the repair process. We have found that Ras/Raf/ERK...

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PMID: 15467460
DOI: 10.4161/cc.3.10.1182

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