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Article

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.

Cell stem cell - 4 Dec 2008

Williams Jon P, Wu Jianqiang, Johansson Gunnar, Rizvi Tilat A, Miller Shyra C, Geiger Hartmut, Malik Punam, Li Wenling, Mukouyama Yoh-suke, Cancelas Jose A, Ratner Nancy

Abstract excerpt

Defining growth factor requirements for progenitors facilitates their characterization and amplification. We characterize a peripheral nervous system embryonic dorsal root ganglion progenitor population using in vitro clonal sphere-formation assays. Cells differentiate into glial cells, smooth muscle/fibroblast (SM/Fb)-like cells, and neurons. Genetic and pharmacologic tools revealed that sphere formation...

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Source

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Identifiers

PMID: 19041782
DOI: 10.1016/j.stem.2008.10.003
PMCID: PMC3487385

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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