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Article

Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge.

Brain : a journal of neurology - 1 Jul 2013

Gomez-Sanchez Jose Antonio, Gomis-Coloma Clara, Morenilla-Palao Cruz, Peiro Gloria, Serra Eduard, Serrano Manuel, Cabedo Hugo

Abstract excerpt

The number of Schwann cells is fitted to axonal length in peripheral nerves. This relationship is lost when tumorigenic stimuli induce uncontrolled Schwann cell proliferation, generating tumours such us neurofibromas and schwannomas. Schwann cells also re-enter the cell cycle following nerve inju...

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Identifiers

PMID: 23748155
DOI: 10.1093/brain/awt130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23748155-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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