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Article

Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation.

Cancer cell - 1 Feb 2008

Zheng Huarui, Chang Lou, Patel Neha, Yang Jiong, Lowe Lori, Burns Dennis K, Zhu Yuan

Abstract excerpt

Recent evidence suggests that alterations in the self-renewal program of stem/progenitor cells can cause tumorigenesis. By utilizing genetically engineered mouse models of neurofibromatosis type 1 (NF1), we demonstrated that plexiform neurofibroma, the only benign peripheral nerve sheath tumor with potential for malignant transformation, results from Nf1 deficiency in fetal stem/progenitor cells of peripheral...

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Identifiers

PMID: 18242512
DOI: 10.1016/j.ccr.2008.01.002

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation.PMID 18242512Read ↗

Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform NeurofibromasSemantic proximity Read ↗

The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells.Semantic proximity Read ↗

How does the Schwann cell lineage form tumors in NF1?Semantic proximity Read ↗

Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromasSemantic proximity Read ↗

Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins.Semantic proximity Read ↗

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.Semantic proximity Read ↗

Ras/Raf/ERK signalling and NF1: Implications for Neurofibroma FormationSemantic proximity Read ↗

Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1.Semantic proximity Read ↗

Neurofibroma Development in Neurofibromatosis Type 1: Insights from Cellular Origin and Schwann Cell Lineage DevelopmentSemantic proximity Read ↗

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase.Semantic proximity Read ↗

Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor <i>Nf1</i> gene loss to promote malignant peripheral nerve sheath tumor formationSemantic proximity Read ↗

Tumor Suppressor Mutations and Growth Factor Signaling in the Pathogenesis of NF1-Associated Peripheral Nerve Sheath TumorsSemantic proximity Read ↗

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