<i>In Vivo</i> Regulation of TGF-β by R-Ras2 Revealed through Loss of the RasGAP Protein NF1

Abstract excerpt

Ras superfamily proteins participate in TGF-β-mediated developmental pathways that promote either tumor suppression or progression. However, the specific Ras proteins, which integrate in vivo with TGF-β signaling pathways, are unknown. As a general approach to this question, we activated all Ras proteins in vivo by genetic deletion of the RasGAP protein Nf1 and examined mice doubly deficient in a Ras protein to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neuroblastoma Research and Treatments
• Share to Neurofibromatosis and Schwannoma Cases
• Share to TGF-β signaling in diseases