Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EGFR-Stat3 signalling in nerve glial cells modifies neurofibroma initiation.

Oncogene - 23 Mar 2017

Wu J, Liu W, Williams J P, Ratner N

Abstract excerpt

Neurofibromatosis type 1 (NF1) is an inherited disease in which affected patients are predisposed to develop benign Schwann cell (SC) tumours called neurofibromas. In the mouse, loss of Nf1 in the SC lineage causes neurofibroma formation. The tyrosine kinase receptor EGFR is expressed in Schwann cell precursors (SCP), which have been implicated in plexiform neurofibroma initiation. To test if EGFR activity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Interleukin-6
Share to Janus Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurofibroma

Share to Neurofibromin 1

Share to Neuroglia

Share to STAT3 Transcription Factor

Share to Tumor Burden

Source

Open in PubMed Open full text

Identifiers

PMID: 27748759
DOI: 10.1038/onc.2016.386
PMCID: PMC5502541

Genes

EGFR
CNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EGFR-Stat3 signalling in nerve glial cells modifies neurofibroma initiation.PMID 27748759Read ↗

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.Semantic proximity Read ↗

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma InitiationSemantic proximity Read ↗

Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromasSemantic proximity Read ↗

Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins.Semantic proximity Read ↗

How does the Schwann cell lineage form tumors in NF1?Semantic proximity Read ↗

Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications.Semantic proximity Read ↗

Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo PathwaySemantic proximity Read ↗

NeurofibromatosisSemantic proximity Read ↗

Pathogenesis of Plexiform Neurofibroma: Tumor-Stromal/Hematopoietic Interactions in Tumor ProgressionSemantic proximity Read ↗

Ras/Raf/ERK signalling and NF1: Implications for Neurofibroma FormationSemantic proximity Read ↗

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling.Semantic proximity Read ↗

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.