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A novel apoptosis pathway activated by the carboxyl terminus of p21

6 Oct 2004

Abstract excerpt

Delivery of biologically active peptides into cells may help elucidate intracellular signal transduction pathways, identify additional in vivo functions, and develop new therapeutics. Although p21 was first identified as a major regulator of cell cycle progression, it is now clear that p21 subserves multiple functions. The amino terminus of p21 interacts with cyclins and cyclin-dependent kinases, while the...

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PMID: 15466931
DOI: 10.1182/blood-2004-06-2188

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